effect of vitamin supplementation on serum oxidized low-density lipoprotein levels in male subjects with cardiovascular disease risk factors

objective(s) oxidized low-density lipoproteins (ox-ldls) appear to play a significant role in atherogenesis. in fact, circulating ox-ldl concentrations have been recognized as a risk factor for cardiovascular disease (cvd). the main objectives of this study were to assess the effects of antioxidant vitamins on ox-ldl as a biomarker of cvd in male subjects with cvd risk factors. materials and methods the effect of antioxidant vitamins on ox-ldl as a biomarker of cvd in male subjects with cvd in male subjects with cvd risk factors at baseline and after 12 weeks of supplementation with vitamin e (400 iu), c (500 mg), ß-carotene (15 mg), and the combined supplements (e, c, and ß-carotene) respectively defined as group e, c, b and control group was considered as group p. results the mean values for ox-ldl at the baseline were 86.93 ± 26.30 u/l in group c, 94.52 ± 38.40 u/l in group e, 79.73±2.07 u/l in group b, 85.97±23.07 u/l in combined group, and 84.90± 14.66 u/l in group p. after 12 weeks of intervention the percentage of changes for group c, group e, group b, com group, and group p were (-18.32), (-2286), (-17.31), (-19.01) and (-2.0), respectively. using wilcoxon method, significant differences were detected in the mean ox-ldl concentrations of baseline and after intervention, values in the c, e, b and combined groups (p< 005). conclusion this study illustrated that diet supplemented with vitamin c (500 mg), vitamin e (400 iu), ß-carotene (15 mg), and the combination of these vitamins was associated with lower serum ox-ldl levels.